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ACROBiosystems Cynomolgus Fc gamma RIIA / CD32a Protein, His Tag (SPR & BLI & HPLC verified)
Brand: ACROBiosystems CDA-C52H7-100ug
Additional Details : Weight : 0.00010kg
Description
Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells. CD32A is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells), where inhibitory ITIMbearing receptors may also be coexpressed and coengaged by specific ligands. CD32A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as CD32B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.1 kDa. The protein migrates as 27-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
| NP_001270598.1 | |
| 100 μg | |
| Gln 28 - Pro 208 | |
| CD32a,FCGR2A,CD32,FCG2 ,FCGR2A1,IGFR2 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by reduced SDS-PAGE |
| 22.1 kDa | |
| Cynomolgus CD32a, His Tag (SPR and BLI and HPLC verified) (CDA-C52H7) is expressed from human 293 cells (HEK293). It contains AA Gln 28 - Pro 208 (Accession # Q8SPW4-1). | |
| -20°C | |
| Fc gamma RIIA / CD32a | |
| Cynomolgus Monkey | |
| PBS, pH7.4 | |
| HEK293 | |
| MABSol™ Fc Receptors |