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ACROBiosystems Cynomolgus Fc gamma RIIA / CD32a Protein, His Tag (SPR & BLI & HPLC verified)

Brand:  ACROBiosystems CDA-C52H7-100ug

Additional Details : Weight : 0.00010kg

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Product Code. 16447349

  • 3799.50 NOK / 100µg
Estimated Shipment: 23-01-2023
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Description

Description

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells. CD32A is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells), where inhibitory ITIM­bearing receptors may also be coexpressed and co­engaged by specific ligands. CD32A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as CD32B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.1 kDa. The protein migrates as 27-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_001270598.1
22.1 kDa
100 µg
Gln 28 - Pro 208
CD32a,FCGR2A,CD32,FCG2 ,FCGR2A1,IGFR2
Unconjugated
PBS, pH7.4
HEK293
Cynomolgus
Powder
>90% as determined by reduced SDS-PAGE
Cynomolgus CD32a, His Tag (SPR and BLI and HPLC verified) (CDA-C52H7) is expressed from human 293 cells (HEK293). It contains AA Gln 28 - Pro 208 (Accession # Q8SPW4-1).
-20°C
Fc gamma RIIA / CD32a
His Tag
Less than 1.0 EU / µg by the LAL method.
MABSol™ Fc Receptors
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