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Cyclin D2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1710.33 NOK - 4836.10 NOK

Specifications

Antigen Cyclin D2
Concentration 0.3 mg/mL
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16847653
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Proteintech
10934-1-AP-20UL
20 μL
1710.33 NOK
20µL
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16837653
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Proteintech
10934-1-AP-150UL
150 μL
4836.10 NOK
150µL
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Description

Description

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.
Specifications

Specifications

Cyclin D2
Western Blot
Unconjugated
Rabbit
Human, Mouse
P30279, P30280
12444, 894
Cyclin D2 Fusion Protein Ag1377
Primary
-20°C
CCND2
0.3 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
CCND2, cyclin D2, G1/S-specific cyclin-D2
CCND2
IgG
Antigen Affinity Chromatography
Antibody
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SDS
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Documents

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