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Cyclin D2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Product Code. 16837653 Shop All Proteintech Products
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Quantity:
150 μL
20 μL
Unit Size:
150µL
20µL
Product Code. Quantity unitSize
16837653 150 μL 150µL
16847653 20 μL 20µL
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Product Code. 16837653

Brand: Proteintech 109341AP150UL

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This item is not returnable. View return policy

Description

Rabbit Polyclonal Antibody

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.

Specifications

Antigen Cyclin D2
Applications Western Blot
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene CCND2
Gene Accession No. P30279, P30280
Gene Alias CCND2, cyclin D2, G1/S-specific cyclin-D2
Gene Symbols CCND2
Host Species Rabbit
Immunogen Cyclin D2 Fusion Protein Ag1377
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12444, 894
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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