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Cyclin D2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 10934-1-AP-20UL
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Description
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.Specifications
| Cyclin D2 | |
| Polyclonal | |
| Unconjugated | |
| CCND2 | |
| CCND2, cyclin D2, G1/S-specific cyclin-D2 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 12444, 894 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 0.3 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| P30279, P30280 | |
| CCND2 | |
| Cyclin D2 Fusion Protein Ag1377 | |
| 20 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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