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CISD2 Mouse anti-Human, Mouse, Rat, Zebrafish, Clone: 3D7A3, Proteintech
Mouse Monoclonal Antibody
Brand: Proteintech 66082-1-IG-150UL
This item is not returnable.
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Description
This monoclonal antibody is specific to CISD2 and does not cross-react with CISD1.
Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.Specifications
| CISD2 | |
| Monoclonal | |
| 1.65 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q7T326, Q8N5K1, Q9CQB5 | |
| cisd2 | |
| Protein A | |
| RUO | |
| 295457, 393354, 493856, 67006 | |
| -20°C | |
| Liquid |
| Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
| 3D7A3 | |
| Unconjugated | |
| CISD2 | |
| CDGSH iron sulfur domain 2, CDGSH2, CISD2, CISD2-Specific, ERIS, Miner1, MitoNEET related 1 protein, NAF 1, WFS2, ZCD2 | |
| Mouse | |
| 150 μL | |
| Primary | |
| Human, Mouse, Rat, Zebrafish | |
| Antibody | |
| IgG2b |