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CHFR Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12169-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16889713

  • 3468.15 NOK / 150µL
Estimated Shipment: 16-12-2022
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Description

Description

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the ′Lys-48′-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of ′Lys-63′-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at ′Lys-63′ are usually not targeted for degradation, but are rather involved in signaling cellular stress.
Specifications

Specifications

CHFR
Polyclonal
Unconjugated
CHFR
CHFR, RING finger protein 196, RNF116, RNF196
Rabbit
Antigen Affinity Chromatography
RUO
231600, 288734, 55743
-20°C
Liquid
Western Blot, Immunohistochemistry (Paraffin)
0.27 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q810L3, Q96EP1
Chfr
CHFR Fusion Protein Ag2811
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
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