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CD172a (SIRP alpha) Monoclonal Antibody (P84), Functional Grade, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
90300.00 NOK - 150400.00 NOK
Specifications
| Antigen | CD172a (SIRP alpha) |
|---|---|
| Clone | P84 |
| Concentration | 1 mg/mL |
| Applications | Flow Cytometry, Functional Assay |
| Classification | Monoclonal |
Description
This P84 MAb reacts with mouse CD172a, also known as signal regulatory protein a (SIRPa). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, macrophages, dendritic cells, but not on T and B lymphocytes. Moreover, neurons and other tissues of the central nervous system have also been shown to express CD172a. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis. This MAb has been reported to have neutralizing activity.
CD172a (SIRP alpha) Monoclonal antibody specifically detects CD172a (SIRP alpha) in Mouse samples. It is validated for Flow Cytometry, Functional AssaySpecifications
| CD172a (SIRP alpha) | |
| 1 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with no preservative; pH 7.2 | |
| AI835480; Bit; Brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; brain immunological-like with tyrosine-based motifs; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172; CD172 alpha; CD172 antigen-like family member A; CD172a; inhibitory receptor SHPS-1; Macrophage fusion receptor; macrophage membrane protein MFP150; Mfr; mSIRP-alpha1; Myd1; MYD-1; MyD-1 antigen; p84; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHP-1; SHPS1; SHPS-1; signal regulatory protein alpha; signal-regulatory protein alpha; signal-regulatory protein alpha-1; Signal-regulatory protein alpha-2; Signal-regulatory protein alpha-3; Sirp; Sirpa; SIRPalpha; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3; swc3; swine workshop cluster 3 antigen; swine workshop cluster 3 antigen precursor; tyrosine phosphatase SHP substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1 | |
| IgG1 κ | |
| Affinity chromatography | |
| Antibody |
| P84 | |
| Flow Cytometry, Functional Assay | |
| Functional Grade | |
| Rat | |
| Mouse | |
| P97797 | |
| 19261 | |
| Primary | |
| 4° C | |
| SIRPA |
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