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  6. CD172a (SIRP alpha) Monoclonal Antibody (P84), Functional Grade, eBioscience™, Invitrogen™
  7. 17161172

CD172a (SIRP alpha) Monoclonal Antibody (P84), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-1721-025

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Product Code. 17161172

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Description

Description

This P84 MAb reacts with mouse CD172a, also known as signal regulatory protein a (SIRPa). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, macrophages, dendritic cells, but not on T and B lymphocytes. Moreover, neurons and other tissues of the central nervous system have also been shown to express CD172a. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis. This MAb has been reported to have neutralizing activity.

CD172a (SIRP alpha) Monoclonal antibody specifically detects CD172a (SIRP alpha) in Mouse samples. It is validated for Flow Cytometry, Functional Assay
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD172a (SIRP alpha)
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.2
P97797
Rat
25 mg
Primary
Mouse
Antibody
IgG1 κ
Flow Cytometry, Functional Assay
P84
Functional Grade
SIRPA
AI835480; Bit; Brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; brain immunological-like with tyrosine-based motifs; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172; CD172 alpha; CD172 antigen-like family member A; CD172a; inhibitory receptor SHPS-1; Macrophage fusion receptor; macrophage membrane protein MFP150; Mfr; mSIRP-alpha1; Myd1; MYD-1; MyD-1 antigen; p84; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHP-1; SHPS1; SHPS-1; signal regulatory protein alpha; signal-regulatory protein alpha; signal-regulatory protein alpha-1; Signal-regulatory protein alpha-2; Signal-regulatory protein alpha-3; Sirp; Sirpa; SIRPalpha; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3; swc3; swine workshop cluster 3 antigen; swine workshop cluster 3 antigen precursor; tyrosine phosphatase SHP substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1
Affinity chromatography
RUO
19261
4° C
Liquid
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