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CD16 Monoclonal Antibody (3G8), NovaFluor™ Blue 555, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen H006T03B03
This item is not returnable.
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Description
This 3G8 monoclonal ab reacts with human and Non-human Primate CD16,also known aslow-affinity Fc gamma RIII. CD16 exists as two distinct isoforms, Fc gamma RIIIA and Fc gamma RIIIB. In humans, Fc gamma RIIIA is expressed as a polypeptide-anchored form on monocytes, macrophages, and lymphocytes such as NK cells. T and B cells do not express this Fc receptor. Fc gamma RIIIB is also detected on neutrophils as a GPI-anchored form. Expression of CD16 on lymphocytes and monocytes is similar in Non-human Primates. However, while CD16 is not found on neutrophils in macaques and baboons, this receptor is detected on these cells in sooty mangabeys. Binding of IgG leads to activation of signal transduction pathways, resulting in ab-dependent cell-mediated cytotoxicity(ADCC), phagocytosis, cytokine release, and antigen presentation. Based on cross-blocking studies 3G8 recognizes the same epitope as CB16. However, 3G8 and B73.1 ab clones bind distinct epitopes.
Applications Reported: This 3G8 ab has been reported for use in flow cytometric analysis.
Applications Tested: This 3G8 ab has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. This may be used at 4uL(0.6ug) per test. A test is defined as the amount(ug) of ab that will stain a cell sample in a final volume of 100uL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 496 nm; Emission: 555 nm; Laser: 488 nm(Blue) Laser
CD16 Monoclonal antibody specifically detects CD16 in Baboon, Chimpanzee, Cynomolgus Monkey, Human, Non-human Primate, Rhesus Monkey samples. It is validated for Flow Cytometry
Specifications
| CD16 | |
| Monoclonal | |
| 4 μL/Test | |
| PBS with no preservative; pH 7.2 | |
| A3RFZ7, O75015, P08637 | |
| Mouse | |
| 100 Tests | |
| Primary | |
| Baboon, Chimpanzee, Cynomolgus Monkey, Human, Non-human Primate, Rhesus Monkey | |
| Antibody | |
| IgG1 |
| Flow Cytometry | |
| 3G8 | |
| NovaFluor Blue 555 | |
| FCGR3A | |
| 4833442P21Rik; CD16; CD16-2; CD16A; CD16a antigen; CD16B; CD32; CD32 receptor 2; CDw32; cytolytic trigger molecule G7; Fc fragment of IgG intermediate affinity IV receptor; Fc fragment of IgG low affinity IIIa receptor; Fc fragment of IgG receptor IIIa; Fc fragment of IgG receptor IIIb; Fc fragment of IgG, low affinity III, receptor for (CD16); Fc fragment of IgG, low affinity IIIa, receptor; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc fragment of IgG, low affinity III, receptor for (CD16); Fc fragment of IgG, low affinity IIIb, receptor (CD16b); Fc gamma receptor III; Fc gamma receptor IIIa; Fc gamma receptor III-A; Fc gamma receptor IIIb; Fc gamma RIIIa; Fc gammaRIV; Fc receptor, IgG, low affinity III; Fc receptor, IgG, low affinity IV; Fc receptor-like 3; Fcg receptor III; FCG2; FCG3; Fc-gamma receptor III-2 (CD 16); Fc-gamma receptor IIIb (CD 16); Fc-gamma receptor IIIb (CD16); Fc-gamma RII-b; Fc-gamma RII-c; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; fc-gamma RIIIb; fc-gamma RIII-beta; Fc-gamma-RIIb; Fc-gamma-RIIc; FcgammaRIII; FcgammaRIII a.1; FcgammaRIII a.2; FcgammaRIII a.3; FcgammaRIIIA; FcgammaRIV; FCGR2; FCGR2A; FCGR2B; FCGR2C; FCGR3; Fcgr3a; FCGR3B; Fcgr4; FCGRIII; FcgRIV; FCR-10; FcRII-b; FcRII-c; FcRIII; FCRIIIA; FCRIIIb; Fcrl3; IGFR3; IgG Fc gamma receptor III; IgG Fc receptor III; igG Fc receptor III-1; IgG Fc receptor III-2; IMD20; immunoglobulin G Fc receptor III; Low affinity immunoglobulin gamma Fc region receptor III; low affinity immunoglobulin gamma Fc region receptor III-A; Low affinity immunoglobulin gamma Fc region receptor III-B; Low affinity immunoglobulin gamma Fc region receptor IV; neutrophil-specific antigen NA; RP11-5K23.1; transmembrane receptor FcgammaRIII-X | |
| Affinity chromatography | |
| RUO | |
| 2214, 2215, 720006 | |
| 4° C, store in dark, DO NOT FREEZE! | |
| Liquid |
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