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ACROBiosystems Biotinylated Human Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His, Avitag™&Tag Free
Biotinylated Protein
Brand: ACROBiosystems IT5-H82Wa-25ug
Additional Details : Weight : 0.00010kg
Description
Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
Biotinylated Human ITGAV&ITGB5 Heterodimer Protein, His,Avitag&Tag Free, produced by co-expression of ITGAV and ITGB5, has a calculated MW of 114.7 kDa (ITGAV) and 81.9 kDa (ITGB5). Subunit ITGAV is fused with an acidic tail at the C-terminus and followeSpecifications
| NP_002201.1 (ITGAV) and NP_002204.2 (ITGB5) | |
| 25 μg | |
| Phe 31 - Val 992 (ITGAV) and Gly 24 - Asn 719 (ITGB5) | |
| Integrin alpha V beta 5,ITGAVandITGB5 | |
| Precision Avi | |
| His Tag and Avi Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 114.7 kDa (ITGAV) and 81.9 kDa (ITGB5) | |
| Biotinylated Human ITGAV&ITGB5; Heterodimer Protein, His,AviTag&Tag; Free (IT5-H82Wa) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) and Gly 24 - Asn 719 (ITGB5) (Accession # P06756-1 (ITGAV) and P18084-1 (ITGB5)). | |
| -20°C | |
| Integrin alpha V beta 5 | |
| Human | |
| 50 mM Tris, 150 mM NaCl, pH7.5 | |
| HEK293 | |
| MABSol™ Biotin Labeled Proteins |