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ACROBiosystems Biotinylated Human Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His, Avitag™&Tag Free
Biotinylated Protein
5297.56 NOK - 23309.24 NOK
Specifications
Accession Number | NP_002201.1 (ITGAV) and NP_002204.2 (ITGB5) |
---|---|
Molecular Weight (g/mol) | 114.7 kDa (ITGAV) and 81.9 kDa (ITGB5) |
Source | Biotinylated Human ITGAV&ITGB5; Heterodimer Protein, His,AviTag&Tag; Free (IT5-H82Wa) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) and Gly 24 - Asn 719 (ITGB5) (Accession # P06756-1 (ITGAV) and P18084-1 (ITGB5)). |
Immunogen | Phe 31 - Val 992 (ITGAV) and Gly 24 - Asn 719 (ITGB5) |
Storage Requirements | -20°C |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
16437809
|
ACROBiosystems
IT5-H82WA-200UG |
200 μg |
23309.24 NOK
200µg |
Estimated Shipment: 11-04-2024 Log in to see stock. |
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16447809
|
ACROBiosystems
IT5-H82WA-25UG |
25 μg |
5297.56 NOK
25µg |
Estimated Shipment: 11-04-2024 Log in to see stock. |
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Description
Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
Biotinylated Human ITGAV&ITGB5 Heterodimer Protein, His,Avitag&Tag Free, produced by co-expression of ITGAV and ITGB5, has a calculated MW of 114.7 kDa (ITGAV) and 81.9 kDa (ITGB5). Subunit ITGAV is fused with an acidic tail at the C-terminus and followeSpecifications
NP_002201.1 (ITGAV) and NP_002204.2 (ITGB5) | |
Biotinylated Human ITGAV&ITGB5; Heterodimer Protein, His,AviTag&Tag; Free (IT5-H82Wa) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) and Gly 24 - Asn 719 (ITGB5) (Accession # P06756-1 (ITGAV) and P18084-1 (ITGB5)). | |
-20°C | |
Integrin alpha V beta 5 | |
Human | |
50 mM Tris, 150 mM NaCl, pH7.5 | |
HEK293 | |
MABSol™ Biotin Labeled Proteins |
114.7 kDa (ITGAV) and 81.9 kDa (ITGB5) | |
Phe 31 - Val 992 (ITGAV) and Gly 24 - Asn 719 (ITGB5) | |
Integrin alpha V beta 5,ITGAVandITGB5 | |
Precision Avi | |
His Tag and Avi Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |