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ACROBiosystems Biotinylated Human ErbB3 / Her3 Protein, His, Avitag™
Biotinylated Protein
5341.70 NOK - 23503.49 NOK
Specifications
Accession Number | NP_001973.2 |
---|---|
Molecular Weight (g/mol) | 72.4 kDa |
Source | Biotinylated Human ErbB3, His,Avitag (ER3-H82E6) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Thr 643 (Accession # P21860-1). |
Immunogen | Ser 20 - Thr 643 |
Storage Requirements | -20°C |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
16447509
|
ACROBiosystems
ER3-H82E6-25UG |
25 μg |
5341.70 NOK
25µg |
Estimated Shipment: 08-05-2024 Log in to see stock. |
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16437509
|
ACROBiosystems
ER3-H82E6-200UG |
200 μg |
23503.49 NOK
200µg |
Estimated Shipment: 08-05-2024 Log in to see stock. |
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Description
ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 72.4 kDa. The protein migrates as 95-105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
NP_001973.2 | |
Biotinylated Human ErbB3, His,Avitag (ER3-H82E6) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Thr 643 (Accession # P21860-1). | |
-20°C | |
ErbB3 | |
Human | |
PBS, pH7.4 | |
HEK293 | |
MABSol™ Biotin Labeled Proteins |
72.4 kDa | |
Ser 20 - Thr 643 | |
ERBB3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3 | |
Precision Avi | |
His Tag and Avi Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by reduced SDS-PAGE |