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ACROBiosystems Biotinylated Human ErbB3 / Her3 Protein, His, Avitag™
Biotinylated Protein
Brand: ACROBiosystems ER3-H82E6-25ug
Additional Details : Weight : 0.00010kg
Description
ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 72.4 kDa. The protein migrates as 95-105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
| NP_001973.2 | |
| 25 μg | |
| Ser 20 - Thr 643 | |
| ERBB3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3 | |
| Precision Avi | |
| His Tag and Avi Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by reduced SDS-PAGE |
| 72.4 kDa | |
| Biotinylated Human ErbB3, His,Avitag (ER3-H82E6) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Thr 643 (Accession # P21860-1). | |
| -20°C | |
| ErbB3 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| MABSol™ Biotin Labeled Proteins |