CAS RN 934660-93-2

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MedChemExpress Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK1 inhibitor with an IC50 of 4.2 nM for MEK1.

Molecular Weight (g/mol)	531.31
Color	White
Physical Form	Solid
Chemical Name or Material	Cobimetinib
Grade	Research
SMILES	OC1([C@H]2NCCCC2)CN(C1)C(C3=C(C(F)=C(C=C3)F)NC4=C(C=C(C=C4)I)F)=O
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.79%
CAS	934660-93-2
Solubility Information	DMSO : ≥ 100 mg/mL (188.21 mM) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Synonym	GDC-0973 XL518
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₁H₂₁F₃IN₃O₂
Formula Weight	531.31