missing translation for 'onlineSavingsMsg'
Learn More

ZO-2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 18900-1-AP-150UL

Additional Details : Weight : 0.00010kg

 View more versions of this product

Product Code. 16888734

  • 3468.15 NOK / 150µL
Estimated Shipment: 20-12-2022
to see stock.

Please to purchase this item. Need a web account? Register with us today!


Description

Description

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and maligt, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.
Specifications

Specifications

ZO-2
Polyclonal
Unconjugated
TJP2
Tight junction protein 2, Tight junction protein ZO 2, TJP2, X104, ZO 2, ZO2, ZO-2, Zona occludens protein 2, Zonula occludens protein 2
Rabbit
Antigen Affinity Chromatography
RUO
115769, 21873, 9414
-20°C
Liquid
Western Blot, Immunofluorescence, Immunocytochemistry
0.19 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q9UDY2, Q9Z0U1
TJP2
ZO-2 Fusion Protein Ag13534
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers