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XPG Rabbit anti-Human, Polyclonal, Proteintech

Product Code. p-7204060 Shop All Proteintech Products
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Quantity:
150 μL
20 μL
Unit Size:
150µL
20µL
Product Code. Quantity unitSize
16848333 20 μL 20µL
16838333 150 μL 150µL
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Product Code. 16848333

Brand: Proteintech 113311AP20UL

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Description

Rabbit Polyclonal Antibody

Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3′ incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.

Specifications

Antigen XPG
Applications Immunoprecipitation, Western Blot, Immunocytochemistry, Immunofluorescence
Classification Polyclonal
Concentration 0.19 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene ERCC5
Gene Accession No. P28715
Gene Alias COFS3, ERCC5, ERCM2, UVDR, XPG, XPGC
Gene Symbols ERCC5
Host Species Rabbit
Immunogen XPG Fusion Protein Ag1874
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2073
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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