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Gibco™ Wnt Surrogate-Fc Fusion Recombinant Protein

Product Code. 17875410
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Quantity:
100 μg
25 μg
500 μg
Unit Size:
100µg
25µg
500µg
Product Code. Quantity unitSize
17875410 25 μg 25µg
17885410 100 μg 100µg
17895410 500 μg 500µg
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Product Code. 17875410

Brand: Gibco™ PHG0401

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Description

Recombinant Protein

Gibco Wnt Surrogate-Fc Fusion Protein activates similar Wnt signaling pathways as most commercially available recombinant Wnt3a proteins or Wnt-conditioned media, while requiring a fraction of the amount of protein or hassle. Gibco Wnt Surrogate-Fc Fusion Protein was engineered with improved solubility, overcoming a major obstacle of working with Wnt3a and reducing the concentrations required to activate Wnt signaling in your model system. Gibco Wnt Surrogate-Fc Fusion Protein is comprised of the LRP-binding domain of DKK linked to a selective, high affinity binder of Frizzled receptors. Gibco Wnt Surrogate-Fc Fusion Protein is provided at a concentration of 2 mg/mL which is equivalent to 17.1 μM based on dimeric stoichiometry. Storage: Store undiluted Gibco Wnt Surrogate-Fc Fusion Protein at -80° for up to 1 year. After thawing, apportion into working aliquots and store at -20°C to -80°C for up to 2 months.

Wnt3a, part of the WNT gene family, consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P56704
Concentration 2 mg/mL
For Use With (Application) Functional Assay
Formulation 25 mM tris with 500 mM NaCl and no preservative; pH 8.2
Gene ID (Entrez) 89780
Name Wnt Surrogate-Fc Fusion
Quantity 25 μg
Source HEK293 cells
Regulatory Status RUO
Endotoxin Concentration 1 EU/mL
Gene Alias MGC119418; MGC119419; MGC119420; Protein Wnt-3 A; vestigial tail; vt; wingless-related MMTV integration site 3 A; wingless-type MMTV integration site family member 3 A; wingless-type MMTV integration site family, member 3 like; wingless-type MMTV integration site family, member 3 A; Wnt 3 A; Wnt family member 3 A; wnt[a]; wnt3; wnt3 l; wnt3 like; Wnt3a; Wnt-3 A; WNT3A protein; wnt3l; Zwnt[a]
Common Name WNT3A
Gene Symbol WNT3A
Biological Activity Greater than 25 fold induction in Topflash assay activity (at a Wnt surrogate-Fc protein concentration between 0.03 - 5.0 nM (based on dimeric stoichiometry))
Conjugate Unconjugated
Recombinant Recombinant
Content And Storage -20°Cor to +80°C if preferred
Expression System HEK293 cells
Form Liquid
Purity or Quality Grade >95%
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