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Valproic acid, MedChemExpress

Product Code. 16496757
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Product Code. 16496757 Supplier Medchem Express Supplier No. HY10585

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Description

MedChemExpress Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches.

Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches.

Specifications

Chemical Name or Material Valproic acid
Physical Form Liquid
CAS 99-66-1
Color Light Yellow
Quantity 5 g
Purity Grade Notes Research
Molecular Formula C8H16O2
For Use With (Application) Cancer-Kinase/protease
Synonym VPA 2-Propylpentanoic Acid
Solubility Information DMSO : 100 mg/mL (693.43 mM; Need ultrasonic) ∣H2O : 1 mg/mL (6.93 mM; Need ultrasonic and warming)
SMILES CCCC(CCC)C(O)=O
Molecular Weight (g/mol) 144.21
Formula Weight 144.21
Percent Purity 98.0%
Grade Research
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