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Thermo Scientific Chemicals U-73122, 95%

Produktkod. 15465189
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Produktkod. 15465189 Leverantör Thermo Scientific Chemicals Leverantörsnummer J62898.M^
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Beskrivning

CAS: 112648-68-7 | C29H40N2O3, C29H40N2O3 | 464.65 g/mol

It is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73343 (sc-201422) is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Inhibitor of phospholipase C activation and inhibits the down regulation of muscarinic receptors.

TRUSTED_SUSTAINABILITY

Kemiska identifierare

CAS 112648-68-7
Molecular Formula C29H40N2O3
Synonym 1-[6-[((17beta)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]pyrrole-2,5-dione

Specifikationer

Quantity 1 mg
Description Off-white
For Use With (Application) Inhibitor of phospholipase C activation and inhibits the down regulation of muscarinic receptors
Formula Weight 464.65g/mol
Solubility Soluble in DMSO, ethanol, or DMF at approx. 0.5mg/ml; May require heating or overnight mixing; Insoluble in water
Product Type Signal Transduction Reagent
Form Crystalline solid
Assay ≥99%

RUO – Research Use Only

Produkttitel
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