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TUSC4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16866353 Shop All Proteintech Products
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20 μL
150 μL
Unit Size:
150µL
20µL
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16866353 20 μL 20µL
16856353 150 μL 150µL
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Product Code. 16866353 Supplier Proteintech Supplier No. 101571AP20UL

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Description

Rabbit Polyclonal Antibody

NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events.

Specifications

Antigen TUSC4
Applications Western Blot, Immunohistochemistry (Paraffin), Immunoprecipitation
Classification Polyclonal
Concentration 0.26 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene NPRL2
Gene Accession No. Q8WTW4, Q9WUE4
Gene Alias G21 protein, Gene 21 protein, tumor suppressor candidate 4, TUSC4
Gene Symbols Nprl2
Host Species Rabbit
Immunogen TUSC4 Fusion Protein Ag0210
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10641, 363138, 56032
Target Species Mouse, Rat, Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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