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  6. Invitrogen™ TRA-1-81 (Podocalyxin) Monoclonal Antibody (TRA-1-81), eBioscience™, Invitrogen™

Invitrogen™ TRA-1-81 (Podocalyxin) Monoclonal Antibody (TRA-1-81), eBioscience™, Invitrogen™

Product Code. p-7218895
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Quantity:
2 mg
10 mg
Unit Size:
10mg
2mg
Product Code. Quantity unitSize
17110692 2 mg 2mg
17120692 10 mg 10mg
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Product Code. 17110692

Brand: Invitrogen™ 14888337

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Description

Mouse Monoclonal Antibody

The TRA-1-81 antibody recognizes a protein expressed on undifferentiated human embryonic stem cells (ES), embryonic carcinoma cells (EC), and embryonic germ cells (EG). Like other stem cell specific markers, the epitope recognized by the TRA-1-81 antibody is lost upon cell differentiation. The TRA-1-81 epitope is resistant to neuraminidase digestion, unlike the epitope recognized by the related TRA-1-60 antibody. The TRA-1-81 antibody is known to specifically recognize a carbohydrate epitope on a keratan sulfated glycoprotein recently identified as podocalyxin, a member of the CD34-related family of sialomucins. Podocalyxin is a transmembrane glycoprotein originally identified on epithelial glomerular cells known as podocytes, and the protein has also been implicated in the development of aggressiveness in a variety of cancers, including breast and prostate cancer.

TRA-1-81 is a cell surface antigen expressed along with SSEA-3, SSEA-4 and TRA-1-60 in human embryonic stem cells, embryonal carcinoma cells and induced pluripotent stem cells (iPS). These surface markers are down-regulated during the differentiation process. In contrast, SSEA-1 is absent in undifferentiated human stem cells but is present on the cell surface after retinoic acid mediated differentiation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRA-1-81 (Podocalyxin)
Applications Flow Cytometry, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone TRA-1-81
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Alias GCTM-2 antigen; Gp200; PC; PCLP; PCLP1; PCLP-1; Podocalyxin; podocalyxin like; podocalyxin-like; podocalyxin-like protein 1; PODXL; TRA180; tra1-81
Host Species Mouse
Purification Method Affinity chromatography
Quantity 2 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgM
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