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Tolfenamic acid, 99+%, Thermo Scientific™
NSAID that activates calcium-activated potassium channels
Brand: Thermo Scientific Alfa Aesar J61256.09
| Quantity | 10g |
|---|
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Description
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
ApplicationsTolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 µM.
Solubility
Soluble in water (slightly), acetone (∼10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (∼10 mg/ml) and ethanol (50 mg/ml).
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
Chemical Identifiers
| 13710-19-5 | |
| 261.705 | |
| YEZNLOUZAIOMLT-UHFFFAOYSA-N | |
| 610479 | |
| 2-(3-chloro-2-methylanilino)benzoic acid |
| C14H12ClNO2 | |
| MFCD00133865 | |
| tolfenamic acid, clotam, n-3-chloro-2-methylphenyl anthranilic acid, 2-3-chloro-2-methylphenyl amino benzoic acid, tolfedine, acido tolfenamico, acide tolfenamique, acidum tolfenamicum, tolfine, n-2-methyl-3-chlorophenyl anthranilic acid | |
| CHEBI:32243 | |
| CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O |
Specifications
| 13710-19-5 | |
| MFCD00133865 | |
| UN2811 | |
| tolfenamic acid, clotam, n-3-chloro-2-methylphenyl anthranilic acid, 2-3-chloro-2-methylphenyl amino benzoic acid, tolfedine, acido tolfenamico, acide tolfenamique, acidum tolfenamicum, tolfine, n-2-methyl-3-chlorophenyl anthranilic acid | |
| YEZNLOUZAIOMLT-UHFFFAOYSA-N | |
| 2-(3-chloro-2-methylanilino)benzoic acid | |
| 610479 | |
| 261.7 | |
| Tolfenamic acid |
| C14H12ClNO2 | |
| 10g | |
| 14,9513 | |
| Soluble in water (slightly),acetone (∽10mg/ml),DMSO (52mg/ml at 25°C),methanol (∽10mg/ml) and ethanol (50mg/ml). | |
| CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O | |
| 261.705 | |
| CHEBI:32243 | |
| ≥99% |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- Tolfenamic acid
Signal Word
- Danger
Hazard Category
- Acute toxicity Category 3
Hazard Statement
- H301-Toxic if swallowed.
Precautionary Statement
- P264-Wash face, hands and anyexposed skin thoroughly after handling.
- P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
Supplemental information
- MIXTURE LIST-Contains : Tolfenamic acid
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