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Invitrogen™ TNIK Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA120639
This item is not returnable.
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Description
Suggested positive controls for this product are heart, skeletal muscle and brain. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
TNIK or TRAF2 and NCK interacting kinase is characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function. TNIK is mainly expression in brain, heart, and spleen and it is a specific effector of RAP2 which regulate actin cytoskeleton. TNIK is autophosphorylated in a manner dependent upon lys54 in the ATP-binding pocket of its kinase domain and plays a main role in cytoskeleton regulation. TNIK has also been shown to phosphorylate gelsolin, the principal intracellular and extracellular actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton.
Specifications
| TNIK | |
| Polyclonal | |
| Unconjugated | |
| TNIK | |
| 1500031A17Rik; 4831440I19Rik; AI451411; C530008O15Rik; C630040K21Rik; KIAA0551; RGD1561817; Tnik; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 23043, 665113 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 0.01% sodium azide | |
| P83510, Q9UKE5 | |
| TNIK | |
| Synthetic peptide. Exact sequence is proprietary. | |
| 25 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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