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Invitrogen™ TNIK Polyclonal Antibody
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Product Code. 11586232
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Quantity:
25 μL
Unit Size:
25µg
Product Code. Quantity unitSize
11586232 25 μL 25µg
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Product Code. 11586232

Brand: Invitrogen™ PA120639

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This item is not returnable. View return policy

Description

Rabbit Polyclonal Antibody

Suggested positive controls for this product are heart, skeletal muscle and brain. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TNIK or TRAF2 and NCK interacting kinase is characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function. TNIK is mainly expression in brain, heart, and spleen and it is a specific effector of RAP2 which regulate actin cytoskeleton. TNIK is autophosphorylated in a manner dependent upon lys54 in the ATP-binding pocket of its kinase domain and plays a main role in cytoskeleton regulation. TNIK has also been shown to phosphorylate gelsolin, the principal intracellular and extracellular actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton.
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Specifications

Antigen TNIK
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.01% sodium azide
Gene TNIK
Gene Accession No. P83510, Q9UKE5
Gene Alias 1500031A17Rik; 4831440I19Rik; AI451411; C530008O15Rik; C630040K21Rik; KIAA0551; RGD1561817; Tnik; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase
Gene Symbols TNIK
Host Species Rabbit
Immunogen Synthetic peptide. Exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 25 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23043, 665113
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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