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TNF alpha Mouse anti-Human, Mouse, Clone: 7B8A11, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 60291-1-IG-20UL

Additional Details : Weight : 0.00010kg

 View more versions of this product

Product Code. 16847365

  • 1415.13 NOK / 20µL
Estimated Shipment: 13-10-2023
to see stock.

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Description

Description

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Specifications

Specifications

TNF alpha
Monoclonal
1.48 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P01375, P06804
TNF
TNF alpha Fusion Protein Ag11413
20 μL
Primary
Mouse, Human
Antibody
IgG2b
Western Blot, Immunohistochemistry (Paraffin)
7B8A11
Unconjugated
TNF
Cachectin, DIF, TNF, TNF a, TNF alpha, TNFA, TNF-a, TNFSF2, TNFalpha, Tumor necrosis factor
Mouse
Protein A
RUO
21926, 7124
-20°C
Liquid
Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers