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TMP21 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 15199-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16884274

  • 3468.15 NOK / 150µL
Estimated Shipment: 13-12-2022
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Description

Description

TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer′s disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.
Specifications

Specifications

TMP21
Polyclonal
Unconjugated
TMED10
P24(DELTA), p24delta, S31I125, S31III125, TMED10, Tmp 21 I, TMP21, Transmembrane protein Tmp21
Rabbit
Antigen Affinity Chromatography
RUO
10972, 68581, 84599
-20°C
Liquid
Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
0.19 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P49755, Q63584, Q9D1D4
Tmed10
TMP21 Fusion Protein Ag7347
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
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