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TIMP2 Monoclonal Antibody (3A4), Invitrogen™

Product Code. 11364593
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Quantity:
500 μL
Unit Size:
500µL
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Product Code. Quantity unitSize
11364593 500 μL 500µL
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Product Code. 11364593 Supplier Invitrogen Supplier No. MA512207

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Description

Mouse Monoclonal Antibody

MA5-12207 targets TIMP-2 in IHC (P) and WB applications and shows reactivity with Bovine, Guinea Pig, Human, mouse, Rabbit, and Rat samples. The MA5-12207 immunogen is a synthetic peptide from the N-terminal region of human TIMP-2 protein.

TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TIMP2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 3A4
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene TIMP2
Gene Accession No. P16035, P16368, P25785, P30121, Q9TRZ7, Q9WUC6
Gene Alias Collagenase inhibitor; CSC-21K; D11Bwg1104e; DDC8; etID32613.12; fa96h09; Metalloproteinase inhibitor 2; metalloproteinase inhibitor 2a; metalloproteinase inhibitor precursor; metalloproteinase inhibitor TIMP-2; metalloproteinase-2; similar to metalloproteinase inhibitor; testicular secretory protein Li 57; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP metallopeptidase inhibitor 2a; TIMP2; Timp-2; TIMP-2 protein; timp2a; tissue inhibitor of matrix metalloproteinase-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinase 2 precursor; tissue inhibitor of metalloproteinase 2a; tissue inhibitor of metalloproteinase-2; tissue inhibitor of metalloproteinase-2 precursor; tissue inhibitor of metalloproteinases 2; tissue inhibitor of mettaloproteinase 2; wu:fa96h09; zgc:136726
Gene Symbols TIMP2
Host Species Mouse
Immunogen A synthetic peptide from the N-terminal region of human TIMP-2 protein
Purification Method Protein A
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100008689, 100135629, 21858, 282093, 29543, 7077
Target Species Bovine, Guinea Pig, Human, Mouse, Rabbit, Rat
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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