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Synaptotagmin-1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 14511-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16883174

  • 3468.15 NOK / 150µL
Estimated Shipment: 13-12-2022
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Description

Description

This antibody recognizes endogenous SYT1, which has an experimentally determined molecular mass of 65-68 kDa. An additional band of 47 kDa could also be detected, which is corresponding to the calculated molecular weight of SYT1.

Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release. Studies indicate that synaptotagmin′s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane. It has been demonstrated that discrete residues within the c (2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Further, Synaptotagmin 1 binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca (2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has been reported. Synaptotagmin 1 can also bind to at least three additional proteins in a Ca (2+)-independent manner; these are neurexins, syntaxin and AP2. Diseases associated with the dysfunction of Synaptotagmin 1 include food-borne botulism and infant botulism.
Specifications

Specifications

Synaptotagmin-1
Polyclonal
Unconjugated
SYT1
P65, SVP65, Synaptotagmin 1, synaptotagmin I, SYT, SYT1, SytI
Rabbit
Antigen Affinity Chromatography
RUO
20979, 6857
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
0.2 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P21579, P46096
SYT1
Synaptotagmin-1 Fusion Protein Ag5970
150 μL
Primary
Mouse, Human
Antibody
IgG
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