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STF 083010, Tocris Bioscience™

Product Code. 18004672
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Product Code. 18004672 Supplier Tocris Bioscience Supplier No. 4509/10

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Description

Inhibits IRE1α endonuclease activity

Inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 307543-71-1
Molecular Formula C15H11NO3S2
Molecular Weight (g/mol) 317.377
InChI Key AUXKGDNZANYAPX-RAXLEYEMSA-N
Synonym regid_for_cid_6537512, stf hplc, n-2-hydroxy-1-naphthyl methylene-2-thiophenesulfonamide, e-n-2-hydroxynaphthalen-1-yl methylene thiophene-2-sulfonamide, n-z-2-oxonaphthalen-1-ylidene methyl thiophene-2-sulfonamide
PubChem CID 6537512
IUPAC Name N-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]thiophene-2-sulfonamide
SMILES C1=CC=C2C(=C1)C=CC(=O)C2=CNS(=O)(=O)C3=CC=CS3

Specifications

Quantity 10 mg
Formula Weight 317.38
Percent Purity >98%
Chemical Name or Material STF 083010
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