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Sitravatinib, MedChemExpress

Product Code. p-200096769
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Product Code. Quantity unitSize
16489747 5 mg 5mg
16477196 100 mg 100mg
16441236 200 mg 200mg
16407228 10 mg 10mg
16403247 50 mg 50mg
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Product Code. 16489747

Brand: Medchem Express HY16961

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Description

MedChemExpress Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.

Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.

Specifications

Chemical Name or Material Sitravatinib
CAS 1123837-84-2
Color Off-White
Purity Grade Notes Research
Molecular Formula C33H29F2N5O4S
Quantity 5 mg
Synonym MGCD516 MG-516
Solubility Information DMSO : ≥ 32 mg/mL (50.82 mM)
SMILES O=C(C1(C(NC2=CC=C(F)C=C2)=O)CC1)NC3=CC=C(OC4=C5C(C=C(C6=NC=C(CNCCOC)C=C6)S5)=NC=C4)C(F)=C3
Molecular Weight (g/mol) 629.68
Formula Weight 629.68
Percent Purity 98.2%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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