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SETD7 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 24840-1-AP-20UL
Additional Details : Weight : 0.00010kg
Description
Histone methyltransferase that specifically monomethylates ′Lys-4′ of histone H3. H3 ′Lys-4′ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates ′Lys-189′ of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates ′Lys-372′ of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated ′Lys-372′ of p53/TP53 in vitro.Specifications
SETD7 | |
Polyclonal | |
Unconjugated | |
SETD7 | |
H3 K4 HMTase SETD7, KIAA1717, KMT7, Lysine N methyltransferase 7, SET7, SET7/9, SET9, SETD7 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
689954, 73251, 80854 | |
-20°C | |
Liquid |
Immunofluorescence, Western Blot, Immunocytochemistry | |
0.41 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
Q8VHL1, Q8WTS6 | |
Setd7 | |
SETD7 Fusion Protein Ag18219 | |
20 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |