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SC144 hydrochloride, MedChemExpress

Product Code. 16476836
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Product Code. 16476836

Brand: Medchem Express HY15614A

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Description

MedChemExpress SC144 hydrochloride is a first-in-class, orally active gp130 (IL6-beta) inhibitor.

SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling. SC144 hydrochloride induces apoptosis in human ovarian cancer cells.

Specifications

Chemical Name or Material SC144 hydrochloride
CAS 917497-70-2
Color Gray
Purity Grade Notes Research
Molecular Formula C16H12ClFN6O
Quantity 100 mg
Solubility Information DMSO : 10 mg/mL (27.87 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES O=C(C1=NC=CN=C1)NNC2=NC3=C(N4C2=CC=C4)C=CC(F)=C3.[H]Cl
Molecular Weight (g/mol) 358.76
Formula Weight 358.76
Percent Purity 98.89%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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