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  6. Invitrogen™ RT1.D Monoclonal Antibody (OX-17), Biotin

Invitrogen™ RT1.D Monoclonal Antibody (OX-17), Biotin
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Product Code. p-7177931
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15338340 100 μg 100µg
15348340 500 μg 500µg
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Product Code. 15338340 Supplier Invitrogen™ Supplier No. MA517435

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Description

Mouse Monoclonal Antibody

anti-rat RT1.D monoclonal antibody recognizes a monomorphic determinant on the α chain of the rat Ia antigen and appears to be the rat homologue of mouse Ia-E. It recognizes the rat Ia product present on B, but not T cells from lymph node or thoracic duct lymph. It does not bind to thymocytes or erythrocytes. The antibody does not cross-react with rat Ia-A or mouse Ia-E antigen, but rabbit antibody raised against the antibody affinity column-purified MRC OX-17 antigen cross-reacted on tissues of mice expressing Ia-E mouse antigen but not on those mouse strains that were Ia-E antigen negative.

RT1.D is a gene located within the major histocompatibility complex (MHC) region of the rat genome, specifically part of the RT1 complex. RT1.D, along with its counterpart RT1.B, comprises class II MHC genes, which are key players in the adaptive immune response. These genes encode for proteins that present extracellularly derived peptides to helper T cells (CD4+ T cells), facilitating the activation and regulation of immune responses. The RT1.D gene product is analogous to human HLA-DR and mouse I-A/I-E molecules, playing an essential role in antigen presentation and immune recognition. RT1.D genes are highly polymorphic, which influences susceptibility to various diseases and are often utilized in studies involving autoimmune diseases, immune response, and transplantation immunology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RT1.D
Applications Flow Cytometry, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone OX-17
Concentration 0.1 mg/mL
Conjugate Biotin
Formulation PBS with 4-5mg/mL BSA and 0.02% sodium azide
Gene RT1-Db1
Gene Accession No. P18211
Gene Alias Db1; MHC class II RT1D beta1 chain antigen; rano class II histocompatibility antigen, D-1 beta chain; rat class I D; RT1 class II histocompatibility antigen, D-1 beta chain; RT1 class II, locus Db1; RT1-D beta; RT1-Db; RT1-Db1; RT1-Db1n
Gene Symbols RT1-Db1
Host Species Mouse
Immunogen Rat spleen membrane glycoproteins depleted of Ia-A antigens.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 294270
Target Species Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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