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ACROBiosystems Rhesus macaque Siglec-2 / CD22 Protein, His Tag
Brand: ACROBiosystems SI2-R52Ha-100ug
Additional Details : Weight : 0.00010kg
Description
B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 76.9 kDa. The protein migrates as 95-120 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
| XP_014979161.1 | |
| 100 μg | |
| Ser 20 - Arg 686 | |
| CD22,SIGLEC2,BL-CAM,SIGLEC-2,Siglec2,SIGLEC2FLJ22814 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 76.9 kDa | |
| Rhesus macaque Siglec-2, His Tag (SI2-R52Ha) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Arg 686 (Accession # EHH29920.1). | |
| -20°C | |
| Siglec-2 | |
| Rhesus Macaque | |
| PBS, pH7.4 | |
| HEK293 | |
| Bio-Markers and CD Antigens |