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Retinoic Acid, All Trans Isomer, MP Biomedicals™

Product Code. 11441771 Shop All MP Biomedicals Products
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Product Code. 11441771 Supplier MP Biomedicals Supplier No. 02190269.5

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Description

Mediates the functions of vitamin A required for growth and development. Retinoic Acid, All Trans Isomer, MP Biomedicals has been used in various differentiation protocols, including B-cells, T cells and neurons, and is applied clinically to treat cancer

Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule. It affects gene transcription and modulates a wide variety of biological processes, including cell proliferation and differentiation, including apoptosis.

  • Retinoic Acid mediated gene transcription depends on the rate of transport of Retinoic Acid to target cells and the timing of exposure of Retinoic Acid to RARs (Retinoic Acid Receptors) in the target tissues.
  • All-trans-Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR).
  • The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells.
  • Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA.
  • Retinoic acid primes embryonic stem cells to become neurons.
TRUSTED_SUSTAINABILITY

Chemische Identifikatoren

CAS 302-79-4
Molecular Formula C20H28O2
Molecular Weight (g/mol) 300.44
MDL Number MFCD00001551
InChI Key SHGAZHPCJJPHSC-YCNIQYBTSA-N
Synonym retinoic acid, tretinoin, vitamin a acid, all-trans-retinoic acid, trans-retinoic acid, renova, airol, retin-a, vesanoid, atra
PubChem CID 444795
ChEBI CHEBI:15367
SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O

Spezifikation

Melting Point 173°C to 183°C
Quantity 500 mg
Solubility Information Soluble in methanol, chloroform (40mg/mL) or acetone (30mg/mL), slightly soluble in ethanol.
IUPAC Name (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
Formula Weight 300.4
Physical Form Powder
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