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  8. Regorafenib monohydrate, MedChemExpress

Regorafenib monohydrate, MedChemExpress

Product Code. p-200097262
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16484866 100 mg 100mg
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16410207 50 mg 50mg
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Product Code. 16484866 Supplier Medchem Express Supplier No. HY10331A

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Description

MedChemExpress Regorafenib (BAY 73-4506) monohydrate is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib monohydrate shows very robust antitumor and antiangiogenic activity.

Regorafenib (BAY 73-4506) monohydrate is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib monohydrate shows very robust antitumor and antiangiogenic activity.

Specifications

Chemical Name or Material Regorafenib monohydrate
CAS 1019206-88-2
Color Orange
Purity Grade Notes Research
Molecular Formula C21H17ClF4N4O4
Quantity 100 mg
Synonym BAY 73-4506 monohydrate
Solubility Information DMSO : 50 mg/mL (99.83 mM; Need ultrasonic)
SMILES O=C(NC1=CC=C(C(C(F)(F)F)=C1)Cl)NC2=CC=C(OC3=CC(C(NC)=O)=NC=C3)C=C2F.O
Molecular Weight (g/mol) 500.83
Formula Weight 500.83
Percent Purity 97.96%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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