missing translation for 'onlineSavingsMsg'
Learn More

RBBP8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12624-1-AP-20UL

Additional Details : Weight : 0.00010kg

 View more versions of this product

Product Code. 16890434

  • 1281.92 NOK / 20µL
Estimated Shipment: 19-12-2022
to see stock.

Please to purchase this item. Need a web account? Register with us today!


Description

Description

CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disruppted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.
Specifications

Specifications

RBBP8
Polyclonal
Unconjugated
RBBP8
CtBP interacting protein, CTIP, DNA endonuclease RBBP8, RBBP 8, RBBP8, RIM, SAE2
Rabbit
Antigen Affinity Chromatography
RUO
225182, 291787, 5932
-20°C
Liquid
Western Blot
0.13 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
B1WC58, Q80YR6, Q99708
Rbbp8
RBBP8 Fusion Protein Ag3314
20 μL
Primary
Human, Rat, Mouse
Antibody
IgG
Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers