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  6. STEMCELL Technologies Rapamycin

STEMCELL Technologies Rapamycin

Product Code. p-7217633
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Quantity:
1 mg
10 mg
Unit Size:
10mg
1mg
Product Code. Quantity unitSize
15682517 1 mg 1mg
17130212 10 mg 10mg
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Product Code. 15682517

Brand: STEMCELL Technologies 73362

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Description

Antibiotic; mTOR pathway inhibitor; Inhibits FKBP-12

  • Rapamycin is a macrolide antibiotic and immunosuppressive compound that inhibits mammalian target of rapamycin (mTOR) signaling
  • It acts through formation of a complex with cytosolic FK-binding protein 12 (FKBP-12), which directly binds to mTOR complex 1 (mTORC1)
  • Its immunosuppressive effects are mediated through inhibition of IL-2 signaling that is critical for T-cell proliferation and activation (Gibbons et al.; Kay et al.) Rapamycin shows antifungal activity against Candida albicans and other fungi (Vézina et al.)
  • Inhibits growth of MDA-MB-468 human breast cancer cells in vitro, and inhibits tumor growth in a mouse xenograft model in vivo (Akcakanat et al.)
  • Induces autophagy in malignant glioma cells (Takeuchi et al.)

Specifications

CAS 53123-88-9
Quantity 1 mg
Percent Purity ≥95%
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