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ACROBiosystems Rabbit Complement C5 Protein, His Tag

Brand:  ACROBiosystems CO5-R52H4-100ug

Additional Details : Weight : 0.00010kg

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Product Code. 16447439

  • 4432.75 NOK / 100µg
Estimated Shipment: 19-01-2023
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Description

Description

Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

This protein carries a polyhistidine tag at the C-terminus. The mature form of Complement C5 is a disulfide-linked heterodimer composed of proteolytically cleaved α and β chain. During cultivation, Complement C5 will be partially processed into α and β c
Specifications

Specifications

XP_008271599.1
73.8 kDa (β chain) and 111.9 kDa (α chain)
100 µg
Gln 19 - Ala 1678
Complement C5,C5,CPAMD4
Unconjugated
PBS, pH7.4
HEK293
Rabbit
Powder
>90% as determined by SDS-PAGE
Rabbit Complement C5, His Tag (CO5-R52H4) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Ala 1678 (Accession # XP_008271599.1).
-20°C
Complement C5
His Tag
Less than 1.0 EU / µg by the LAL method.
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