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Tocris Bioscience™ (R)-2-Hydroxyglutaric acid disodium salt, Tocris Bioscience™

KDM4A inhibitor; also NF-κB activator

Brand:  Tocris Bioscience™ 6124/50

Encompass

Product Code. 15757226

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Description

Description

(R)-2-Hydroxyglutaric acid disodium salt is an oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells and inhibits FTO (mRNA N6-methyladenine demethylase).
Specifications

Specifications

(R)-2-Hydroxyglutaric acid disodium salt
(R)-2-Hydroxypentanedioic acid disodium salt
Soluble to 100mM in water
White
103404-90-6
50 mg
Solid
Bioactive Small Molecule
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