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PYGL Mouse anti-Human, Clone: 1G12D8, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66769-1-IG-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16898945

  • 4593.76 NOK / 150µL
Estimated Shipment: 11-06-2024
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Description

Description

This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specifications

Specifications

PYGL
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P06737
PYGL
PYGL Fusion Protein Ag8550
150 μL
Primary
Human
Antibody
IgG1
Western Blot
1G12D8
Unconjugated
PYGL
GSD6, phosphorylase, glycogen, liver, PYGL
Mouse
Protein G
RUO
5836
-20°C
Liquid
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