Prothymosin alpha Rabbit anti-Human, Polyclonal, Proteintech

Prothymosinalpha(PTalpha) is a nuclear protein that is widely expressed in mammalian tissues, including kidney, liver, spleen, normal lymphocytes, human T cell leukemia virus-infected T cells and myeloma cells. The human PTalpha gene maps to chromosome 2 and encodes a protein that exhibits punctuated nuclear distribution,which correlates to transcription sites. PTalpha is a chromatin-remodeling protein that was initially thought to mediate T lymphocyte maturation,but subsequently has been shown to be involved in cellcycle progression,proliferation and cell differentiation. PTalpha is thought to be transported into the nucleus by the karyopherin beta1-Rch-1 complex, where it associates with Histones H2A, H2B, H3 and H4. Also, PTalpha is phosphorylated on Thr 7 and Thr 12 or 13 by Prothymosin alpha-phosphorylating kinase (PTalphaK) in amitogen activating pathway. The amino terminus of PTalpha iscleaved to produce a secreted, biologically active peptide thymosin alpha1,whichmay be used as an immunomodulatorin cancer patients and patients with chronic active hepatitis,or as an immunoen hancer of vaccinesin immunocompromised individuals.