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Prostaglandin I2 Sodium Salt, MP Biomedicals™

Product Code. 11454201 Shop All MP Biomedicals Products
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Product Code. 11454201 Supplier MP Biomedicals Supplier No. 0215196910

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Description

Inhibits platelet aggregation by antagonizing thromboxane A. Prostaglandin I2 Sodium Salt, MP Biomedicals is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. Prostacyclin therapy improves hemodynamics in pulmonary arteria

Prostaglandin I2 Sodium Salt is a potent fibrinolytic that antagonizes thromboxane A. It relaxes vascular smooth muscle and induces vasodilation. It also increases cyclic AMP concentration in human platelets (IC50 for human platelet aggregation is about 0.001 nM). Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.

Prostaglandin I2 sodium salt stimulates platelet adenylyl cyclase. Nitric oxide is also produced in vascular endothelium, where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 61849-14-7
Molecular Formula C20H31NaO5
Molecular Weight (g/mol) 374.453
InChI Key LMHIPJMTZHDKEW-HIHHSTLZSA-M
PubChem CID 133687047
IUPAC Name sodium;(5Z)-5-[(3aS,4S,5S,6aR)-5-hydroxy-4-[(E,3R)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoate
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)[O-])O2)O)O.[Na+]

Specifications

Quantity 10 mg
Solubility Information PGI2 is a hygroscopic crystalline solid soluble in water.
Formula Weight 374.5
Percent Purity ≥99%
Physical Form Powder
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