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Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Progesterone is a sex hormone required for suppression of estrogen signaling and is also involved in transcriptional activation
• Progesterone maintains the uterine endothelium and sustains pregnancy through suppression of muscle contractility
Applications
• Progesterone signaling is relevant to the study of breast cancer
Literature References
Kim, O.; Park, E.Y.; Kwon, S.Y.; Shin, S.; Emerson, R.E.; Shin, Y.H.; DeMayo, F.J.; Lydon, J.P.; Coffey, D.M.; Hawkins, S.M.; Quilliam, L.A.; Cheon, D.J.; Fernández, F.M.; Nephew, K.P.; Karpf, A.R.; Widschwendter, M.; Sood, A.K.; Bast, R.C. Jr.; Godwin, A.K.; Miller, K.D.; Cho, C.H.; Kim, J. Targeting progesterone signaling prevents metastatic ovarian cancer. Proc Natl Acad Sci U S A. 2020, 117(50), 31993-32004.
Jain, V.; McDonald, S.D.; Mundle, W.R.; Farine, D. Guideline No. 398: Progesterone for Prevention of Spontaneous Preterm Birth. J Obstet Gynaecol Can. 2020, 42(6), 806-812.
Specifications
Specifications
| Melting Point | 126°C to 131°C |
| Color | Brown-Yellow to Yellow |
| Loss on Drying | 0.5% max. (500 mg, 105°C, 2 hrs) |
| Infrared Spectrum | Authentic |
| Assay Percent Range | 97.5% min. (HPLC) |
| Packaging | Glass bottle |
| Quantity | 25 g |
| Merck Index | 15, 7889 |
| Specific Rotation Condition | +190° (20°C c=1,ethanol) |
| Specific Rotation | + 190 |
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Safety and Handling
- Progesterone
- Warning
- Carcinogenicity Category 2
- H351-Suspected of causing cancer.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
RUO – Research Use Only
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