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  8. Prexasertib dihydrochloride, MedChemExpress

Prexasertib dihydrochloride, MedChemExpress

Product Code. 16443596
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Product Code. 16443596

Brand: Medchem Express HY18174A

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Description

MedChemExpress Prexasertib dihydrochloride (LY2606368 dihydrochloride) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of 50=8 nM) and RSK1 (IC50=9 nM). Prexasertib dihydrochloride causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dihydrochloride shows potent anti-tumor activity.

Prexasertib dihydrochloride (LY2606368 dihydrochloride) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of 50=8 nM) and RSK1 (IC50=9 nM). Prexasertib dihydrochloride causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dihydrochloride shows potent anti-tumor activity.

Specifications

Chemical Name or Material Prexasertib dihydrochloride
CAS 1234015-54-3
Color Yellow
Purity Grade Notes Research
Molecular Formula C18H21Cl2N7O2
Quantity 25 mg
Synonym LY2606368 dihydrochloride
Solubility Information DMSO : 8 mg/mL (18.25 mM; Need ultrasonic) ∣H2O : 1 mg/mL (2.28 mM; ultrasonic and warming and heat to 80°C)
SMILES NCCCOC(C=CC=C1OC)=C1C2=CC(NC3=NC=C(C#N)N=C3)=NN2.[H]Cl.[H]Cl
Molecular Weight (g/mol) 438.31
Formula Weight 438.31
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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