missing translation for 'onlineSavingsMsg'
Learn More

PIF1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 19006-1-AP-150UL

Additional Details : Weight : 0.00010kg

 View more versions of this product

Product Code. 16848824

  • 4593.76 NOK / 150µL
Estimated Shipment: 07-06-2024
to see stock.

Please to purchase this item. Need a web account? Register with us today!


Description

Description

PIF1 is a single-stranded (ss) DNA-dependent ATPase as well as a DNA helicase that unwinds DNA in a 5′ to 3′ direction with respect to the DNA strand on which it binds first. This protein is critical to DNA replication and telomere length maintece in Saccharomyces cerevisiae. The PIF1 gene is highly conserved from yeast to humans. Mutations in the gene that encodes for PIF1 cause all telomeres to lengthen, suggesting that the PIF1 functions as a catalytic inhibitor of both new telomere formation and telomere elongation. Human PIF1 preferentially binds telomeric DNA where it inhibits telomerase activity. PIF1 specifically counteracts the RecQ homolog Sgs1 helicase activity, and degradation of PIF1 is mediated by the ubiquitin-26S proteasome pathway.
Specifications

Specifications

PIF1
Polyclonal
Unconjugated
PIF1
C15orf20, PIF, PIF1
Rabbit
Antigen Affinity Chromatography
RUO
208084, 367645, 80119
-20°C
Liquid
Western Blot
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q1HG60, Q80SX8, Q9H611
Pif1
PIF1 Fusion Protein Ag13522
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers