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Invitrogen™ Phospho-MEKK1 (Thr1400) Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5103271

Product Code. 16629724

  • 4685.00 NOK / 100µL

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Description

Description

Antibody detects endogenous levels of MEKK1 only when phosphorylated at Thr1400, which site historically referenced as Thr1402.

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK1 can phosphorylate and activate MAPKK 1 and MAPKK 2 (MEK1/MEK2) which leads to phosphorylation of MAP kinases. It is also a highly efficient activator of the JNK cascade. The protein contains a putative 1 RING-type zinc finger and 1 SWIM-type zinc finger.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-MEKK1 (Thr1400)
Polyclonal
Unconjugated
MAP3K1
MAP/ERK kinase kinase 1; MAP3K1; MAPK/ERK kinase kinase 1; MAPKKK1; MEK kinase 1; MEKK; MEKK 1; Mekk1; mitogen activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; si:rp71-80a19.2; SRXY6
Rabbit
Sequential Chromatography
RUO
116667, 26401, 4214
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P53349, Q13233, Q62925
MAP3K1
A synthesized peptide derived from human MAP3K1(Accession Q13233), corresponding to amino acid residues around phosphorylated Thr1400.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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