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Invitrogen™ Phospho-CPI-17 (Thr38) Polyclonal Antibody
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Product Code. 15534111
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Quantity:
100 μL
Unit Size:
100µL
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15534111 100 μL 100µL
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Product Code. 15534111 Supplier Invitrogen™ Supplier No. PA536842

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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 22 kDa. Purity is >95% by SDS-PAGE.

CPI-17 is a phosphorylation-dependent inhibitory protein for smooth muscle myosin phosphate. CPI-17 was originally identified as a PKC-potentiated inhibitory protein of protein phosphatase-1, which is dominantly expressed in smooth muscle. Phosphorylation at Threonine 38, in vitro, by PKC or Rho-kinase enhances the inhibitory potency toward myosin phosphatase. CPI-17 is also phosphorylated at Threonine 38 by protein kinase N and might be involved in the calcium sensitization of smooth muscle contraction as a downstream effector of Rho and/or arachidonic acid. CPI-17 is dually phosphorylated at Serine 12 and Threonine 38 by a MYPT-associated kinase, M110 kinase.
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Specifications

Antigen Phospho-CPI-17 (Thr38)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene PPP1R14A
Gene Accession No. Q91VC7, Q96A00, Q99MC0
Gene Alias 1110001M11Rik; 17 kDa PKC-potentiated inhibitory protein of PP1; 17-kDa PKC-potentiated inhibitory protein of PP1; 17-KDa protein; Cpi; CPI17; CPI-17; PKC-potentiated inhibitory protein of PP1; PPP1INL; PPP1R14A; Protein kinase C-potentiated inhibitor protein of 17 kDa; protein phosphatase 1 regulatory inhibitor subunit 14A; protein phosphatase 1 regulatory subunit 14A; protein phosphatase 1, regulatory (inhibitor) subunit 14A
Gene Symbols PPP1R14A
Host Species Rabbit
Immunogen Synthetic phosphopeptide derived from human CPI-17 around the phosphorylation site of Threonine 38.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114004, 68458, 94274
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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