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Tocris Bioscience™ PFK 15
Selective PFKFB3 inhibitor
Brand: Tocris Bioscience™ 5339/10
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Description
PFK 15 is an originally reported to be a selective PFKFB3 inhibitor (IC50 = 207 nM); a more recent report failed to demonstrate activity in a PFKFB3 kinase assay. Selective for PFKFB3 over a panel of 96 kinases. Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells. Suppresses glucose uptake and tumor growth, and inhibits metastasis of Lewis lung carcinoma cell xenografts in mice.Specifications
| PFK 15 | |
| 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one | |
| Soluble to 100mM in DMSO | |
| Bioactive Small Molecule |
| 4382-63-2 | |
| 10 mg | |
| Solid |
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Product Title
Research Use Only. Not For Human or Veterinary Use
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