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PELI1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12053-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16889533

  • 3468.15 NOK / 150µL
Estimated Shipment: 19-12-2022
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Description

Description

This antibody may cross react with Pellino-3.

The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.
Specifications

Specifications

PELI1
Polyclonal
Unconjugated
PELI1
PELI1, Pellino 1, pellino homolog 1 (Drosophila), PRISM, Protein pellino homolog 1
Rabbit
Antigen Affinity Chromatography
RUO
305549, 57162, 67245
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin)
0.35 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q8C669, Q96FA3
PELI1
PELI1 Fusion Protein Ag2683
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
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