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Invitrogen™ PDGFRB Monoclonal Antibody (1A2)
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Product Code. 11355493
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Quantity:
100 μL
Unit Size:
100µL
Product Code. Quantity unitSize
11355493 100 μL 100µL
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Product Code. 11355493

Brand: Invitrogen™ MA515529

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This item is not returnable. View return policy

Description

Mouse Monoclonal Antibody

MA5-15529 targets PDGFRb in indirect ELISA, WB applications and shows reactivity with Human and mouse samples. The MA5-15529 immunogen is purified recombinant fragment of human PDGFRb expressed in E. Coli. MA5-15529 detects PDGFRb which has a predicted molecular weight of approximately 190kDa.

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
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Spezifikation

Antigen PDGFRB
Applications ELISA, Western Blot
Classification Monoclonal
Clone 1A2
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene Pdgfrb
Gene Accession No. P05622, P09619
Gene Alias AI528809; Beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140B; CD140b antigen; IBGC4; IMF1; JTK12; KOGS; PDGF beta chain; PDGF Receptor beta; Pdgfr; Pdgfr1; PDGFR-1; PDGFRB; PDGF-R-beta; PDGFR-beta; PENTT; platelet derived growth factor receptor beta; platelet derived growth factor receptor, beta polypeptide; platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; Platelet-derived growth factor receptor, beta; platelet-derived growth factor receptor, beta polypeptide
Gene Symbols Pdgfrb
Host Species Mouse
Immunogen Purified recombinant fragment of human PDGFRb expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18596, 5159
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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